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Dianabol (Methandrostenolone)

Dianabol represents one of the most popular and one of the most important anabolic steroids of all time. Without question, this is the most popular oral steroid to ever hit the market and one of the most popular steroids in any form. While almost always found as an oral tablet, Dianabol can be found as an injectable solution, but the tablets represent the primary route of administration. Why is this steroid so important? In many ways it gave birth to the age of modern performance enhancement. It was not the first anabolic steroid used for that purpose, that would belong to testosterone, but Dianabol would open the door to a new wave of steroid use that has grown beyond what anyone expected.

Dianabol represents one of the only anabolic steroids that was developed for the sole purpose of performance enhancement. The compound did carry listed therapeutic uses at one time, but performance was the true reason this steroid was given life. Through the 1940’s and 50’s the Soviet Union had begun to dominate the Olympic games, and the use of testosterone by many of its athletes left the rest of the world lagging far behind. During this time, U.S. Olympic team Dr. John Ziegler would learn of the U.S.S.R.’s steroid use, and quickly would aid in ensuring his athletes would match up. In 1958, with the help of Dr. Ziegler, Ciba Pharmaceuticals would release the first batches of Methandrostenolone under the trade name Dianabol. The compound was designed in an effort to maintain the anabolic properties of testosterone with less androgenicity in a fast acting, powerful method. Seemingly overnight the steroid was a massive success, giving many U.S. athletes a distinct advantage over their Soviet rivals.

After its inception, Dianabol would quickly find its way into nearly every competitive sport imaginable. In conjunction with exogenous testosterone, this would birth an age of performance unlike the world had ever seen. The steroid would also rapidly become a staple in competitive bodybuilding where it has remained a favorite to this day. However, shortly after its release the U.S. FDA would begin to put a lot of pressure on Ciba in an effort to push the company to list true medical benefits of the steroid. The FDA would approve its use for the treatment osteoporosis in post-menopausal women as well as pituitary-deficient dwarfism, but the latter was withdrawn in the early 1980’s. Again the FDA would pressure Ciba for more information, but in 1983 under mounting pressure Ciba would discontinue the Dianabol tab. A few years later, the FDA would pull all Methandrostenolone brands from the shelf. Since that time Dianabol has not been legally manufactured in the United States, but is still manufactured heavily all over the world.

Dianabol Functions & Traits:

D-Anabol 25 Methandrostenolone is a testosterone derived anabolic androgenic steroid. Officially, it is a structurally altered form of the primary male androgen testosterone. Dianabol is the testosterone hormone with an added double bond at the carbon one and two position. This slight alteration reduces the hormone’s androgenic nature. It also carries an added methyl group at the 17th carbon position that allows the hormone to survive oral ingestion, officially classifying Dianabol as a C17-alpha alkylated steroid. An important note, injectable Dianabol is also C17-alpha alkylated. The end result gives us an anabolic steroid with an androgenic rating of 40-60 with a much lower binding affinity to the androgen receptor compared to testosterone. However, it will also share a much weaker relationship for serum binding protein, which results in an extremely powerful anabolic steroid. If there’s any doubt, this is one extremely powerful anabolic steroid carrying a potent anabolic nature.

On a functional basis, Dianabol is one of the easier anabolic steroids to understand. This steroid will largely provide its anabolic benefits by enhancing protein synthesis, nitrogen retention and glycogenolysis. Protein synthesis represents the rate by which cells build proteins, the building blocks of muscle. Nitrogen retention, this is important as all muscle tissue is comprised of approximately 16% nitrogen. The more nitrogen we retain, the more anabolic we remain. Conversely, a nitrogen deficiency results in a catabolic or muscle wasting state. Then we’re left with glycogenolysis, which refers to the relationship and conversion between glycogen and glucose. Through enhanced glycogenolysis, we are able to make better use of our total carbohydrate consumption. While in many ways these traits are quite simple, they are strong enough to make Dianabol a remarkably powerful anabolic steroid.

Another important trait of Dianabol and perhaps one of the most important of all is the relationship it shares with other anabolic steroids. Dbol as it’s often called is not what we’d label as a base steroid. This is not an anabolic steroid we build a cycle around, but rather one we add to a well-planned stack. Dianabol has the ability to create unbelievable synergy when conjoined with other anabolic steroids. For example, you could supplement with 100mg of Trenbolone, Masteron or Equipoise per day (doses and steroids are simply being used as an example, not actual recommendations) and the results you’d receive from 50mg per day of Trenbolone, Masteron or Equipoise along side 50mg of Dianabol per day would be far more dramatic. You would have an identical amount of total milligrams of anabolic steroids with or without Dianabol, but the added Dianabol would provide greater enhancement.

Effects of Dianabol:

The effects of Dianabol can be summed up as fast acting and dramatic. In fact, it is more than possible for the individual to gain as much as 20lbs of mass in only a few weeks of Dianabol use. Total dosing will play a role, as will total caloric consumption, but a 20lb gain is very realistic. This makes Dianabol a premier off-season bulking steroid, and that will be its most common purpose of use. During this phase of use, the individual should also expect his strength to increase significantly. Dbol is actually one of the best strength increasing steroids on the market and along with mass can produce this result rapidly.

The effects of Dianabol are also greatly appreciated by many athletes; however, it is not as common as it once was in athletic enhancement circles. Due to the possible rapid increases in mass, many athletes will opt for steroids like Anavar or Winstrol, but it generally depends on the purpose of use. Due to the rapid and pronounced increases in strength, which can translate into more power and speed, this can be a solid athletic enhancer. The individual should also experience a level of enhanced recovery and endurance. When it comes to the weight gain, it’s important to remember that this will largely revolve around total caloric intake. While the steroid can promote enormous amounts of mass, you have to feed the body enough calories to reach this end. We wouldn’t call this the best athletic enhancing steroid due to other options, but if strength is the only true concern it could be a decent option.

Then we’re left with the cutting cycle, and you will not find Dianabol in such plans too often. Some competitive bodybuilders will use it early on in a cutting phase in order to maintain fullness, and it will provide lean tissue protection; however, there are better options. One problem with cutting cycle use can be the level of water retention this steroid can provide, which is normally the last thing you want when cutting. Such retention can be controlled, and the ability for this steroid to maintain strength can be appreciated, but there are better options.

Side Effects of Dianabol:

There are several possible side effects of Dianabol use. This is not the most dangerous anabolic steroid of all time, but it can carry a host of potential problems. A healthy adult male can manage the side effects of Dianabol, but you must understand them and how to combat them to pull this off. In order to achieve successful supplementation, we have broken down the possible side effects of Dianabol into their related categories along with all you need to know:

Estrogenic Qualities of Dianabol

Dianabol is a relatively strong estrogenic anabolic steroid due to the moderate level of aromatase activity it carries. While its aromatase activity is only moderate, this conversion actually leads Methandrostenolone to be converted to methylestradiol rather than estradiol, which is far more powerful than estradiol. This can make side effects like gynecomastia and water retention very possible with this steroid; in fact, they can appear seemingly overnight. Heavy water retention can also promote high blood pressure, which Dianabol is notorious for causing. Such effects can be controlled, and when it comes to high blood pressure this is something you’ll need to put some effort into ensuring does not become a problem.

In order to combat the estrogenic side effects of Dianabol, anti-estrogens are commonly recommended when supplementing with this steroid. You have two choices in anti-estrogens, Selective Estrogen Receptor Modulators (SERM’s) like Nolvadex (Tamoxifen Citrate) and Aromatase Inhibitors (AI’s) like Femara (Letrozole). SERM’s can be enough for some men and should be your first choice if they can get the job done. However, AI’s will be far more effective as they will directly inhibit aromatization and reduce serum estrogen levels. Unfortunately, AI’s can negatively affect cholesterol, as can Dianabol, and when conjoined this can prove potentially problematic. If an AI is used cholesterol management will be a priority, and it will be possible. However, SERM’s, while not always as effective will actually promote healthier cholesterol levels due to their estrogenic like activity in the liver.

Androgenic Qualities of Dianabol

Dianabol is not an extremely androgenic steroid, its androgenicity has been structurally reduced, but androgenic side effects are still possible. Such side effects of Dianabol use include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Most men should not have a problem with such effects, response will be the final dictator, but most will remain clear. Although the odds are in your favor, such effects are brought on by Methandrostenolone being metabolized by the 5-alpha reductase enzyme. This is the same enzyme responsible for the reduction of testosterone to dihydrotestosterone, but the overall conversion here will result in very low amounts of dihydromethandrostenolone. This tells us 5-alpha reductase inhibitors like Finasteride that are often used to combat androgenic side effects will have very little if any affect on Dianabol.

Despite its reduced androgenicity, Dianabol can promote virilization symptoms in women. Such symptoms include body hair growth, a deepening of the vocal chords and clitoral enlargement. It is possible for some women to use this steroid without virilization symptoms with extremely low doses, but the odds are not favorable. Most all women should choose anabolic steroids with less translating androgenic activity to meet their needs.

Cardiovascular Effects of Dianabol

Dianabol can have a pronounced negative effect on cholesterol. This includes HDL cholesterol suppression and increases in LDL cholesterol, and the total changes can be significant. It is possible for total cholesterol levels to remain in a healthy range, but it is also possible for this healthy total reading to be misleading if HDL is suppressed heavily. Managing cholesterol during Dianabol use will be extremely important. Repeated use of this steroid as with many anabolic steroids could potentially lead to plaque buildup in the arteries overtime. It’s also extremely important to keep in mind the very possible additional strain on cholesterol brought on by the use of an AI when supplementing with Dianabol as total estrogen reductions will have a negative effect. Again, cholesterol maintenance will be extremely important.

As discussed, Dianabol can also play a negative role on blood pressure, which can be controlled by controlling water retention in most cases. When it comes to the blood pressure and cholesterol issues, the ultimate key to success will be your lifestyle. You should not supplement with this steroid if you already suffer from high blood pressure or cholesterol. If you are healthy enough for use, you should ensure your lifestyle is conducive to their maintenance. This should include a healthy diet that is rich in omega fatty acids, plenty of cardiovascular activity and an avoidance of any activity that promotes the opposite, negative end. Proper estrogen maintenance and control will also be important as estrogen plays an important role in cholesterol management. Yes, it is more than possible to supplement with Dianabol without high blood pressure and cholesterol, but you must put in the effort.

Testosterone Suppression with Dianabol

All anabolic steroids suppress natural testosterone production. While the total rate of suppression varies from one steroid to the next, with Dianabol it is very pronounced. For this reason, most men are encouraged to include some form of exogenous testosterone with their Dianabol use. Failure to include exogenous testosterone, regardless of your genetics or rumors you have heard will lead to a low testosterone condition. Such a condition comes with a host of possible symptoms and is extremely unhealthy. Even if symptoms do not show or are moderate at best, a low level condition will remain an unhealthy one. If you include exogenous testosterone, this problem is solved as the body will have all the testosterone it needs.

Once the use of Dianabol is complete and all the exogenous steroidal hormones have cleared your system, natural testosterone recovery will begin again. Natural recovery assumes no prior low testosterone condition. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) due to improper anabolic steroid use. While natural recovery will begin on its own, it will be slow. For this reason, most are encouraged to implement a Post Cycle Therapy (PCT) plan after anabolic steroid use. Such a plan will commonly include the SERM’s Nolvadex and Clomid, and often additional HCG. This will greatly speed up the recovery process, as well as its overall efficiency. It will not return your natural testosterone levels to normal on its own, if this is something you’ve been told it is a myth. However, it will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise. Total recovery will still take several months, but this will cut the total time down dramatically and ensure a smooth recovery.

Hepatotoxicity of Dianabol

Dianabol is a C17-alpha alkylated anabolic steroid, and as a result, carries a hepatotoxic nature. The rate of hepatotoxicity can vary greatly from one C17-aa steroid to the next, and while Dbol is far from the most toxic, we can’t call it mild either. However, its total toxicity should not lead to liver damage if responsible use is followed and the liver was healthy to begin with. During use, liver enzyme values will increase, but it’s important to remember increases in values does not equate to damage but rather stress and potential damage. In order to avoid damage, use should be limited to 6 weeks of total use. There should also be at least 6 weeks of no C17-aa use before beginning a new course. However, most will not begin a new course until their next cycle.

In order to provide protection, beyond duration of use recommendations there are several points of consideration. When using a C17-aa steroid like Dianabol, it is extremely important that you avoid excess alcohol consumption, as excess will promote tremendous liver stress. In fact, avoiding all alcohol isn’t a bad idea. If that’s not appealing, keep in mind alcohol is perhaps the most anti-performance substance we can put in our body, and your total purpose of Dianabol use is performance enhancement.

Beyond alcohol, you should also avoid all over the counter (OTC) medications when possible. Many OTC medications carry strong hepatic natures, and in some cases, far more pronounced than many anabolic steroids. Use should be limited to when only absolutely necessary. Once all C17-aa steroid use has come to an end, liver detoxifiers supplements are also recommended.

Dianabol Administration:

Standard Dianabol doses will vary tremendously depending on experience and individual desires. Despite internet rumor and myth, a quality Dbol tablet will produce notable results with as little as 15mg per day. However, most will be far more satisfied with a 20-25mg per day dosing. Keep in mind, each time we increase the dose, this increases the probability of negative side effects and makes them more difficult to control. If a positive experience is enjoyed in the 20-25mg range, 30-35mg per day can be attempted if desired. 50mg per day would be the next step up, and that’s a big Dianabol dose, but manageable for the experienced anabolic steroid user. However, many will not need such a dose. Higher doses are not uncommon in some hardcore circles, you can easily find someone taking up to 100mg per day, but such doses cannot be recommended. Doses of this nature will produce side effects and be hard on your health. Even if you can control the visual side effects with such a dose, the internal effects can be a very different story.

Dianabol carries a half-life of 3-5 hours, and many often recommend splitting the daily dose into 2-3 small doses per day in an effort to maintain peak blood levels. However, even with 3 equal doses per day, you will still experience highs and lows in blood levels. Further, the maximum peak blood level will be much lower than it could have been if the total dosing was taken all at once. By taking the total daily dose at once, this will give you a higher peak level that you can time around your training and maximize during the crucial timing window that follows training. Regardless of which method you choose, you will find Dianabol to produce great results.

The final note on Dianabol administration is when to take it during a cycle. The most common point of use is as a kick-start to a new off-season mass gaining cycle. This will give the individual fast and notable gains early on while the slower injectable steroids are building in their system. This type of use will also result in the most dramatic gains in weight. Another option of use is mid-cycle during a period often referred to as plateau busting. During any cycle you will hit a wall and the gains will slow or come to a screeching halt. Introducing Dianabol during this phase will see you break through the plateau or sticking point, and your progress will continue. Due to the hepatotoxicity of Dbol, and due to the fact that most cycles will fall in the 8-12 week range, most will only use Dianabol for one of those purposes during a single cycle. However, in hardcore bodybuilding cycles that often extend well past the 12 week mark, it would be possible to implement both phases of use with necessary C17-aa breaks. Regardless of the type of use, dose or timing schedule you use, you will find Dianabol stacks well with all anabolic steroids. But it should not be used with another C17-aa anabolic steroid.

Availability of Dianabol:

Dianabol is one of the most widely available anabolic steroids on earth. You will not find a steroid supplier that doesn’t carry this product. This includes all online steroids suppliers, and should include any local gym dealer. As an added bonus, this is one of the most affordable steroids on earth. Demand is high, but so is the supply and competition, and this keeps the price down. In fact, you can easily buy 1,000 5mg British Dispensary Anabol tablets, one of the most common and notable brands on earth for as little as $100. Other popular brands include Russian Dbol METAHAPOCTEHOROH by Akrikhin (Akpnxnh), Naposim by Terapia and Anahexia by Jinan Pharmaceuticals. You will also find numerous underground labs carry high dose Dianabol capsules. Most Dbol tablets will normally be found in 5mg and 10mg strength, but capsules are common in 25-50mg strength. Unfortunately, while there are some good capsules, many of them are garbage. Sticking with tablets is normally the best way to go, and they shouldn’t cost that much.

A final note on the availability of Dianabol, while there is an abundant amount of high quality Dbol, counterfeits do exist. Researching your supplier is imperative before making a purchase. This research should also include digging up all information on the Dbol brand of your choice before making a purchase.

Buying Dianabol Online – Warning:

Buying Dianabol online is the easiest way to purchase the steroid, and by far the most affordable. While a gym dealer is convenient, in most cases his prices will be much higher. Most gym dealers are buying Dianabol online themselves and then passing it on to you. While online purchasing is common, it also comes with potential problems. You could be scammed, you could buy a low grade product or you could end up with an outright counterfeit. This makes researching your supplier first hand again imperative. However, there is one more concern that is far greater and will not change regardless of how much research you do. In places like the United States, buying Dianabol online is against the law and a violation of federal law. In the U.S. anabolic steroids are classified as Schedule III controlled substances. You must have a prescription to legally purchase and possess anabolic steroids, and a prescription will only be given on the basis of what’s considered legal medical need. Even if you qualify for a prescription, you will not receive one for Dianabol.

The laws regarding anabolic steroids can vary greatly depending on the country in question. There are several countries that are similarly strict to the U.S. but the U.S. is about as strict as it gets. At the same time, there are many countries that are far more lenient when it comes to anabolic steroids. However, most countries will frown on online purchasing. Regardless of where you live, understanding the law is it pertains to where you live is important. But if you’re looking for high quality anabolics and you want to guarantee your legal safety, you are encouraged to visit the sponsors here at Steroid.com. The sponsors here at Steroid.com can legally provide you high quality anabolics without a prescription or the need for legal concern.

Dianabol Reviews:

D-Anabol 25 Dianabol is simply a fantastic steroid, there’s really no other way to put it. It’s a very simple anabolic steroid, very basic, but like so many things in life sometimes basic can be tremendous. If you’re looking for rapid gains in size that give you a full look, this is the steroid for you. If you’re stuck in a rut and your progress has hit a wall, again this is the steroid for you. There are steroids that can produce similar fast acting results. The anabolic steroid Anadrol (Oxymetholone) is most commonly compared to Dianabol in this regard; however, its potential for negative side effects is greater than Dianabol. Many argue that Anadrol is stronger, but many often use doses of Anadrol much higher than Dbol. Some data has suggested that on a milligram for milligram basis, Dianabol is actually the stronger steroid.

Regardless of its total level of power, which all will agree is high, Dianabol’s place in the history of anabolic steroids is an important one. Athletes have always strived to be the best, and enhancing performance has always been a pursuit. Injecting testicular extract to eating raw animal testicles themselves have all been a part of sports; the latter since sports existed. However, it would be Dianabol that would bring forth the modern age of performance enhancement and the realization of what anabolic steroid use could do in a performance capacity. Oddly enough, for decades those that have supported steroid bans have touted there’s no proof Dianabol actually enhances performance. In fact, there have been official write-ups making this claim. Anyone who has used the steroid knows how ridiculous this is, and if it weren’t it wouldn’t be one of the most sought after anabolic steroids in the world for more than 50 years.

Dianabol Profile:

  • [17a-methyl-17b-hydroxy-1,4-androstadien-3-one]
  • Molecular Weight: 300.44
  • Formula: C20H28O2
  • Melting Point: N/A
  • Manufacturer: Ciba (originally)
  • Effective dose: 15-50mgs per day
  • Active Life: 5 hours
  • Detection Time: up to 6 weeks
  • Anabolic/Androgenic Ratio (Range): 90-210:40-60

Dianabol References:

  1. Serakovskii S, Matskoviak I., Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells, Farmakol Toksikol 1981 Mar-Apr;44(2):213-7
  2. Brain Res. 1998 May 11;792(2):271-6.
  3. Chemfinder. Copyright 2004 CambridgeSoft Corporation. Cambridge, MA, USA.
  4. Br Med J. 1975 May 31;2(5969):471-3.
  5. www.steroid.com
  6. Clin Sci (Lond). 1981 Apr;60(4):457-61
  7. Steroids. 1984 Dec;44(6):485-95.
  8. Vrach Delo. 1983 Nov;(11):34-6. Russian
  9. Acta Med Acad Sci Hung. 1975;32(1):27-34
  10. 4 Nesterin MF, Budik VM, Narodetskaia RV, Soloveva GI, Stoianova VG., Effect of methandrostenolone on liver morphology and enzymatic activity, Farmakol Toksikol 1980 Sep-Oct;43(5):597-601
  11. Anabolic Research Guide, 2005, Brain Clapp

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Dianabol 8 weeks
As you begin to get more comfortable with using it, you could increase your dosages from 30mg – 80mg per day by week 4. For an advanced cycle, aim for 80mg – 100mg per day. Cycles for men should last around 8 weeks, as anything longer could be stressful for the liver. For women, things are much different. Dianabol at 20 mg a day is suppressing, not as much as deca or tren but more than anavar or turinabol. Dianabol will give you with low t. So taking dianabol alone for a cycle is a bad idea. Whereas previously the part of dianabol only cycles was to kick-start results, it is currently an integral portion of the cycle with the trenbolone. Should you do the dbol cycle properly you’ll get muscle and physical strength in a few weeks. For most, a dbol cycle will just represent a small part of a bigger total cycle. The important properties of dianabol and how to get maximum results. Regardless of the dbol dosage you take, its properties do not change. At its heart all dbol dose consists of powerful elements that have very particular androgenic qualities. Its anabolic to androgenic ratio equal is 90-210:40-60 and has a 300. For a whole complete dianabol cycle, you need at least 8 weeks for the maximum results. The 6 weeks cycle will do the same, but some men prefer the 8 weeks cycle involving 2 weeks off which is another healthy technique. Dianabol can improve muscle growth, but this doesn’t mean you should purchase it from anywhere and use it right away. Usually, dianabol is most commonly ran as a kick start (the first 4-6 weeks) to a cycle but some choose to run it as a standalone. Mostly, bodybuilders use it on bulking cycles. Dbol users may experience “wet gains” and have a “puffy” look due to water retention from high estrogen. 50mg/day is the lowest recommended dose for a 12-week cycle. Starting with a low dose might help reduce the side effects to an extent, particularly the water retention. If you do not experience any side effects at 50mg, up the dose to 75 and then subsequently to 100mg/day. Typical anadrol results. So you know that by taking anadrol you’re going to gain a huge amount of strength and muscle; but how much will you gain exactly? from a 4 week cycle, you’re probably looking at 30lbs of weight gain. From an 8 week cycle, you’re more likely to add 45lbs. Run dbol at 25mg/day for 8-weeks along with testosterone (any ester) at 350mg/week. By week 4, when the test kicks-in, you will be strong and huge. Some users even run dianabol at 50mg/day for 4-weeks only, making the most of the cycle at the maximum tolerable dose. Recovery couldn’t begin in week 9, as i’d intend for an 8 week cycle. So i’ll use testosterone enanthate for weeks 1-6, but then switch to testosterone propionate 100 mg/day. I’d end its use in the middle of week 8, so that levels will fall sufficiently for recovery to begin in the next week as planned. 3) test dbol cycle. You cannot say dianabol is used in the testosterone enanthate cycle, but you can surely add testosterone in dianabol cycle. Dianabol cycle length is either 1-4 or 1-6 weeks in which the dosage also varies i. Please join this discussion about 8 week sustanon cycle. Within the anabolic steroids category. Excerpt: i realize that sust is best ran for 10-12 weeks. However i was wondering what your guys opinions were on running it 8 weeks at 600 mg a week Hospital for Special Surgery: “Steroid Side Effects: How to Reduce Drug Side Effects of Corticosteroids, dianabol 8 week cycle results.
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The frequency of severe reactions has been estimated at around 5% to 6%. Psychological effects have been reported on withdrawal of corticosteroids, the frequency of this is unknown, dianabol 8 week cycle results. Frequency not reported : Depression, emotional instability, euphoria, insomnia, mood swings, personality changes, euphoria, psychological dependence [Ref] Hematologic. Frequency not reported : Leucocytosis [Ref] Dermatologic. Alright, so im 8 weeks into my test 500 wk deca 400 wk cycle. I was sceptical about my gear because around week 6 i still didnt feel anything. I gained about 5 pounds, but i thought it was beacuase so much food i was eating. Why would anyone run a dianabol (methandrostenolone) only cycle? if a bodybuilder is looking to gain mass (bulk up) without having to do injections, a dbol only cycle can be very effective and beneficial if ran correctly. Users report gains of 7-15lbs. In only 4-6 weeks with dbol cycles. Anavar cycles for men usually last for 8 weeks, where women will generally cycle anavar for 6-8 weeks. After a cycle is finished, a break is needed from all types of c17-aa steroids, until liver enzyme values are normalized. When it comes to dosage men usually take from 10mg-100mg, and women range from 2. Thus my cycle was gonna be 500 mg/week test and some dbol to kick start it. Reading your article has created doubts for me. Perhaps a longer deca cycle would make more sense, as its long term and milder. Current weight is 165 lb at 6’0. Spent a couple years at a lean 150, but bear moding as lean bulk is almost impossible for me. As you begin to get more comfortable with using it, you could increase your dosages from 30mg – 80mg per day by week 4. For an advanced cycle, aim for 80mg – 100mg per day. Cycles for men should last around 8 weeks, as anything longer could be stressful for the liver. For women, things are much different. Purpose: to bulk up – but stay lean. Meaning, you see your abs but you got more muscles. Results: you can add 10-30lbs of lean muscle if done right. Obviously, first time users will get the best bulking benefits. Dianabol cycle, results after 2 weeks description: in this video we show the results after two weeks of using the dianabol (dbol) cycle. Michel tells us how much mass he has gained and how much he has increased the volume of his chest and biceps for two weeks on the dianabol cycle. Typical anadrol results. So you know that by taking anadrol you’re going to gain a huge amount of strength and muscle; but how much will you gain exactly? from a 4 week cycle, you’re probably looking at 30lbs of weight gain. From an 8 week cycle, you’re more likely to add 45lbs. Usually, dianabol is most commonly ran as a kick start (the first 4-6 weeks) to a cycle but some choose to run it as a standalone. Mostly, bodybuilders use it on bulking cycles. Dbol users may experience “wet gains” and have a “puffy” look due to water retention from high estrogen. Please join this discussion about 8 week sustanon cycle. Within the anabolic steroids category. Excerpt: i realize that sust is best ran for 10-12 weeks. However i was wondering what your guys opinions were on running it 8 weeks at 600 mg a week. Dianabol cycle and dosage for best results. Dianabol, also commonly known as methandrostenolone, and dbol in the bodybuilding community is popular for its outstanding effects which come in forms of large muscle and mass gain, and tremendous strength gain, which is the most sought for effect of anabolic steroids. • 12 week cycle is recommended. • stacking is recommended. • use on training and non training days • dbol is best if taken in the morning. A dbol stack is a group of 2-4 products used together to amplify and maximize results 

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Safest and most dangerous steroids - Ask the Anabolic Doc Ep. 21

Chemical Name: 17a-methyl-17b-hydroxy-1,4-androstadien-3-one
Synonyms: Dianabol (D-bol), Methandienone, Nerobol
Active Half Life: 3 – 6 hours
Anabolic : Androgenic Ratio: 1:1–1:8 (1:1 Testosterone as standard in rodents)

The addition of a methyl group at the 17α position of the D cyclopentane ring slows First Pass Metabolism in the Liver to allow it to remain in circulation longer than testosterone. The double bond between C1 and C2 of the A cyclohexane ring reduces the androgencity of the compound with a weaker relative binding affinity for the androgen receptor (AR) than testosterone.

Methandrostenolone was first reported in the literature in 1955; and soon released in 1958 by Ciba Pharmaceuticals to the US prescription market under the drug name Dianabol. A derivative of testosterone, the compound has been modified to reduce the androgenic and preserve the anabolic properties. Historically, it has been the most commonly used C-17a alkylated oral steroid for physique enhancing purposes but does have its history deep rooted in medical prescriptions also.

Originally developed alongside Dr John Ziegler; a physician for US Olympic teams, in hopes of reducing competition to Russia who were already utilizing testosterone with their athletes, Methandrostenolone brought a new dynamic as a compound with lower androgenicity but with retained anabolic properties, soon causing advancements in competitive sports. However, within 5 years the compound was beginning to trend a new wave in steroid abuse in sports with many athletes disregarding the initial prescription guidelines of 5-15mg.

In 1970, the FDA pushed Ciba for clarification and publiciation of Methandrostenolone’s approved uses and accepted a “probably effective” stance on treating osteoporosis and pituitary deficient dwarfism whilst research continued into its effect on wasting conditions. There are several reports in the literature of its use in childhood dystrophies. By 1983, Ciba withdraw Dianabol from the US market followed by full removal of generic Methandrostenolone by the FDA in 1985. Non-medical use was outlawed in the U.S. under the Anabolic Steroids Control Act of 1990.

The metabolism of Methandrostenolone is mainly in the liver by 6β-hydroxylation, 3α- and 3β-oxidation, 5β-reduction, 17-epimerization, and conjugation among other reactions with excretion occurring via urine.

Human mitochondrial steroid hydroxylating enzymes CYP11B1 and CYP11B2 (non liver native) have also been shown to be capable of metabolizing the compound leading to the formation of 11β-hydroxy and 18-hydroxy metabolites. Unconjugated, beta-glucuronidated and sulfated metabolites have also been observed in the urine. Long-term use of Methandrostenolone at high dosages can lead to the appearance of unmetabolized drug in the urine.

Whilst technically an Anabolic steroid, Methandrostenolone still has androgenic side effects; commonly oily skin and acne (due to sebaceous gland androgenic effects), and body/facial hair growth.

Women should take note of its potential virilizing effects such as deepening on the voice, irregularities in the menstrual cycle, facial hair growth and clitoral enlargement alongside. Clinical history reports of 2 prepubertal girls treated with Dianabol cream by their family physicians during 6 and 8 months because of anal eczema. In both of them, growth velocity and bone maturation was accelerated, and there was hypertrophy of the clitoris and deepening of the voice. All symptoms in one of the girls, with the exception of the deep voice, had disappeared six years after the discontinuation of treatment.

Whilst there is potential for Methandrostenolone to convert via 5-alpha reductase to 5-alpha-dihydroMethandrostenolone, it does so at a very slow rate due to a low binding affinity for the 5-alpha reductase enzyme.

Thyroid Binding Hormone Globulin (THBG) levels have been shown to be effected by as little as 10mg resulting in potentially higher levels of free circulating thyroxine and triiodothyronine.

Due to this structural modification, Methandrostenolone shares similarity to Boldenone (except for the 17α methyl group); aromatizing at the same extent as Boldenone. However, it is much more estrogenic due to its pathway conversion to a 17α-methylestradiol, a potent estrogen metabolite which is metabolism-resistant and more biologically active than estradiol.

Testosterone Suppression (HPTA)
HPTA suppression is observed at moderate dosage due to negative feedback to the Hypothalmic Pituitary Testicular Axis (HPTA); either as a result of elevated estrogen or elevation in serum testosterone level. Methandrostenolone at a dosage of 15 mg was shown to reduce plasma testosterone levels by 69%. Return of normal HPTA function is normally observed following 6-8 weeks discontinuation provided Secondary or Primary Hypogonadism not developing as a result.

Another important clinical observation is a reduction in Sex Hormone Binding Globuin (SHBG) is observed with Methandrostenolone usage, resulting in higher levels of circulating free testosterone.

In females, Methandrostenolone has been shown to cause menstruation issues, resulting in irregularities of menstrual cycle.

Methandrostenolone is a sperm-suppressive agent. At 15 mg for 2 months, sperm density per ml decreased 46% and 73%. Three of the subjects tested had became azoospermic and one of them had only 1 million sperms/ml after two months use of the drug. The percentage of motile cells decreased in two months about 30%. The percentage of sperms with normal configuration decreased significantly both in one and two months, from 73 ± 8% to 65 ± 5% and 42 ± 23%, respectively. The percentage of sperms with amorphous head increased about 100% during two months use. The changes in sperm morphology and production were however observed to be reversible.

Hepatotoxicity (Liver)
Being a C17-α alkylated compound, this protects the molecule from First Pass Liver Metabolism allowing a very high percentage of the compound to enter the bloodstream following oral administration.

The literature is clear in the association of Methandrostenolone with Hepatic Jaundice, Hepatitis, Cholestasis and Liver Parenchyma cell alterations. Cholestatic Jaundice in rare circumstances can result in renal failure and potentially death.

In rare circumstances, liver carcinoma can develop as a result of liver dysfunction in potential combination with environment factors.

Elevations in bilirubin, Alkaline Phosphatase (ALP), Alanine Transferase (ALT) and Aspartate Transferase (AST) should be closely monitored by bloodwork by a physician during and post use.

A case reports of a 28-year-old body builder who was admitted because of jaundice. For 80 days, until 3 weeks before hospitalization, he had been taking 10-50mg Methandrostenolone by mouth, and 50mg stanozolol intramuscularly every other day. Bilirubin concentration was raised to 4.5 mg/dl, cholestasis enzymes were normal, while transaminase activities were raised. Liver biopsy was compatible with cholestasis induced by anabolic steroids. Although the steroids had been discontinued, the patient’s general condition deteriorated over 7 weeks. Serum bilirubin rose up to a maximum of 77.9 mg/dl. In addition renal failure developed with a creatinine concentration of 4.2 mg/dl. The patient’s state improved simultaneously with the administration of ursodeoxycholic acid (UDCA); a bile acid derivative; and the biochemical values gradually reached normal levels after several weeks. In this case there was a notable temporal coincidence between the administration of ursodeoxycholic acid and the marked clinical improvement. As such TUDCA may be a viable compound as prophylactic treatment.

Cardiovascular (Cholesterol / Lipid)
Methandrostenolone has a reported history of causing elevated serum total cholesterol due to elevations in LDL (bad) cholesterol; as well as causing issues with decreased HDL (good) cholesterol. This reduction in serum HDL is mediated by hepatic triglyceride lipase, an enzyme that regulates serum lipids.

Oral C17-α alkylated AAS stimulate hepatic triglyceride lipase, resulting in decreased serum HDL. Injectable administration of AASs has less profound effects on this enzyme because they enter the circulation without passing through the liver.

Kidney (Renal)
Whilst not directly nephrotoxic, Methandostenolone can increase renal artery BP, probably via potentiating the renin–angiotensin-aldosterone system (RAAS) along with the up-regulation of endothelin. RAAS can increase BP and water retention through promoting tubular sodium and water re-absorption. Acute Kidney Injury (AKI) may also result as a correlation to increases in serum creatinine.

Neurochemistry (Neurotoxicity)
In past literature, it has been attempted to associate violent crime to the use of anabolic steroids but the results are inconclusive in light of other poly substance abuse.

No effect was observed on brain reward-performance of methandrostenlone but a small effect has been observed with Testosterone which may influence the sensitivity of the brain reward system. No effect was observed on changes in hippocampal activity in rats treated with Methandrostenolone.

The earliest reports of clinical use have been in pediatrics to treat childhood muscular dystrophy as well as attempting to resolve growth issues in prepubertal male patients.

Further clinical uses for Methandrostenolone focused on reporting increases in nitrogen retention and subsequent decrease in nitrogen excretion (30 % lower) and increase in serum protein values aiding in tissue repair and decrease healing time after surgery, burns, fractures or skin grafts.

There are several reports on its use in geriatric states, debilitation, and after chronic infections (tuberculosis) as well as aiding in calcium retention in osteoporosis and increasing red blood cell count in anemic patients.

Steroid hormone interactions are not just limited to the Androgen Receptor and many published reports have exhibited the interaction of Methandrostenolone with the glucocorticoid receptor; blocking their activation and subsequent anti-inflammatory effect.

Methandrostenolone has also been shown to diminish the rate of production of adrenocortical steroid by inhibiting corticotrophin production or release; resulting in lower circulating cortisol levels.

There is research to also suggest Methandrostenolone can augment insulin resistance in Diabetic patients but further research is required as well as former AAS users potentially through increase in Visceral Adipose Tissue (VAT).

The earliest report of Methandrostenolone being used for physical enhancement was of a dosage of 5mg taken for 3 weeks resulting in a 2.48 kg (5.45 lb) increase in lean muscle mass tissue and has been demonstrated to support maintenance and recovery of strength following a 12 week de-trained period.

As of the mid 2000s, dietary supplements have come under scrutiny due to the potential illegal containment of AAS; most specifically the Prohormones which were readily available at the time. Out of a study of 103 supplements, 3 were found to contain illegal amounts of undisclosed Methandrostenolone within. Consumers are advised from an Anti-Doping perspective to be aware of what is contained within the products they buy, and as such, particular interest has been paid as of late to the detection of AAS in dietary supplements with new methods of detection constantly being developed and improved upon.

Reported Deaths
The majority of reported deaths in the literature causatively to Methandrostenolone use are in association with myocardial infarctions or progression of cardiovascular disease. However, the majority of cases note this as a response to polydrug use and not one particular substance.

As Methandrostenolone is a hepatoxic C17-α alkylated compound, particular attention should be paid to the management of prevention of cholestatic injuries to the liver and management of bile metabolism. Bile acids such as Tauroursodeoxycholic acid (TUDCA) and synthetic bile derivatives such as Ox-Bile should be considered to aid in bile flow; as well as lipotrophic compounds such as Choline and Inositol to aid in fat metabolism within the liver. Supplement Needs Dr Dean St Mart Liver Stack (https://www.supplementneeds.co.uk/products/supplement-needs-liver-stack-240-capsules) is a combination of 1000mg Ox Bile, 800mg TUDCA, 800mg Choline and 800mg Inositol. Care should be taken to not co-administer TUDCA alongside Methandrostenolone due to a plausible ability to increase hepatocyte uptake of Methandrostenlone resulting in enhanced hepatotoxicity.

Originally dosages of 0.1-0.3 mg/kg were prescribed for children in the treatment of muscular dystrophies.

In males, 5mg as a daily dose was the initial prescribing guidelines with no more than 6 weeks consecutive use. This was initially an effective dose but today, in physique enhancement and performance, a dosage of 30-50 mg is commonly observed producing very noticeable and rapid results. A 1981 published athletic performance paper showed a dosage of 100mg was well tolerated for 6 weeks although health markers were not closely monitored. Several other reports in early literature have shown dosages of 0.6mg / kg.

For females, a dosage of 2.5mg was originally prescribed for osteoporosis. However, females should be mindful of the potential virilizing side effects as outlined previously.

Availability Of Dianabol
Methandrostenolone is a controlled substance in the United States and Western Europe, but still remains popular among bodybuilders sourced via the Underground Black Market. However, Methandrostenolone is readily available without a prescription in certain countries as well as also being manufactured in Asia and many East European countries in Black Market Underground Pharmaceutical Facilities such as Alpha Pharma (India) and Balkan Pharmaceuticals (Moldova).

*Steroidal.com has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. You can learn about how we make sure our content is accurate by viewing our editorial policy.

Dianabol History
[Experimental study of dianabol, a new anabolic agent. 17 alpha-Methyl-17 beta-hydroxy-androstane-1,4-diene-3-one].
Schweiz Med Wochenschr. 1959 Dec 12;89:1313-8.

[On the anabolic activity of Methandrostenolone (1-dehydro-17 alpha-methyltestosterone)].
Minerva Med. 1960 Mar 21;51:977-80.

Some experiences with a new anabolic steroid (Methandrostenolone).
Br Med J. 1960 Apr 30;1(5182):1300-5.

[On the problem of the anabolic effect of testosterone derivatives. (A report on experiences with dianabol)].
Med Welt. 1960 May 28;22:1192-205.

[Clinical and experimental studies on the effect of Methandrostenolone].
Helv Med Acta. 1960 Dec;27:514-8.

[Nitrogen balance studies before and after Dianabol].
Helv Med Acta. 1960 Dec;27:543-5.

[New synthetic anabolic preparation: Methandrostenolone].
Dia Med. 1961 Mar 6;33:208-14.

A study of the androgenic and some related effects of methandienone.
Br Med J. 1961 Apr 8;1(5231):998-1003.

[Studies on anabolic agents. I. Comparative study of the anabolic action of Methandrostenolone (MA) and of 19-nortestosterone phenylpropionate (NTP) in the same individuals. II. Anabolic action of a depot form of Methandrostenolone].
J Med (Oporto). 1962 Apr 28;47:979-82.

Methandrostenolone and nandrolone decanoate in muscular dystrophy; a controlled trial.
Neurology. 1963 Jan;13:12-23.

Med Clin (Barc). 1963 May;40:334-46.

Cas Lek Cesk. 1963 Oct 18;102:1148-54.

Br Med J. 1964 Jan 11;1(5375):105-7.

Geneeskd Gids. 1964 Mar 19;42:116-23.

Dtsch Gesundheitsw. 1964 Jul 16;19:1360-3.

South Med J. 1964 Aug;57:909-13.

[Contribution to the study of anabolics].
Bori JV.
Rev Esp Fisiol. 1966 Sep;22(3):121-5.

[The anabolic and androgenic effect of Methandrostenolone in experiments with male rats].
Iodaev NA, Pokrovskiĭ BV.
Vopr Med Khim. 1966 Sep-Oct;12(5):527-32.

Relative androgenic activities of some anabolic steroids as measured by chick comb responses.
Boris A, Ng C.
Steroids. 1967 Mar;9(3):299-305.

Clinical observations with nerobol, an anabolic derivative of testosterone.
Klug W.
Ther Hung. 1968;16(2):61-3.

Anabolic agents: clinical efficacy versus side effects.
Moldawer M.
J Am Med Womens Assoc. 1968 Apr;23(4):352-69.

[Further studies on the radioprotective mode of action of anabolic steroids].
Panek R, Baran S.
Strahlentherapie. 1973 Apr;145(4):443-52.

Prolonged effects of anabolic steroid upon muscular contractile force.
Ariel G.
Med Sci Sports. 1974 Spring;6(1):62-4.

Anabolic and androgenic effects of Methandrostenolone (“Nerobol”) during systematic physical activity in rats.
Rogozkin V.
Br J Sports Med. 1975 Jul;9(2):65-9.

Pharmacological and endocrinological studies on anabolic agents.
Neumann F.
Environ Qual Saf Suppl. 1976;(5):253-64.

Responses to sustained use of anabolic steroid.
Shephard RJ, Killinger D, Fried T.
Br J Sports Med. 1977 Dec;11(4):170-3.


Metabolism and Excretion
[Study of the metabolic effects of an anabolic drug with a steroid structure: Methandrostenolone].
Ann Endocrinol (Paris). 1961 Jan-Feb;22:65-81.

[Metabolic research in man with an anabolic steroid (Methandrostenolone)].
Klin Wochenschr. 1961 Oct 1;39:998-1006.
Nihon Naibunpi Gakkai Zasshi. 1964 Dec 20;40:1155-65.

Acta Endocrinol (Copenh). 1965 Feb;48:313-21.

Effect of steroids with antiandrogenic properties on androgenic and myotrophic activity of testosterone and some of its derivatives.
Ivanenko TI.
Neurosci Behav Physiol. 1980 May-Jun;10(3):227-31.

Methandrostenolone: metabolism in the rabbit.
Templeton JF, Jackson CC, Steele JW.
Eur J Drug Metab Pharmacokinet. 1984 Jul-Sep;9(3):229-33.

[Determination of some androgens and anabolic steroids in human urine by HPLC].
Bi HG, Zhou TH.
Yao Xue Xue Bao. 1989;24(3):207-11.

Effect of extended use of single anabolic steroids on urinary steroid excretion and metabolism.
Harrison LM, Martin D, Gotlin RW, Fennessey PV.
J Chromatogr. 1989 Apr 7;489(1):121-6.

Methandrostenolone metabolism in humans: potential problems associated with isolation and identification of metabolites.
Harrison LM, Fennessey PV.
J Steroid Biochem. 1990 Aug 14;36(5):407-14.

[Imprinting of metabolism of steroid hormones caused by the anabolic steroid drug Methandrostenolone].
Krynetskiĭ EIu, Maruzhenkov DS, Prokhorov BS, Rylin AF.
Probl Endokrinol (Mosk). 1991 Mar-Apr;37(2):45-7.

Metabolism of anabolic steroids in humans: synthesis of 6 beta-hydroxy metabolites of 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, and metandienone.
Schänzer W, Horning S, Donike M.
Steroids. 1995 Apr;60(4):353-66.

Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases.
Kuuranne T, Kurkela M, Thevis M, Schänzer W, Finel M, Kostiainen R.
Drug Metab Dispos. 2003 Sep;31(9):1117-24.

Unexpected Contribution of Cytochrome P450 Enzymes CYP11B2 and CYP21, as Well as CYP3A4 in Xenobiotic Androgen Elimination – Insights From Metandienone Metabolism
Parr MK1, Zöllner A, Fusshöller G, Opfermann G, Schlörer N, Zorio M, Bureik M, Schänzer W.
Toxicol Lett. 2012 Sep 18;213(3):381-91


HPTA / Spermatogenesis
[Effect of an anabolic agent Methandrostenolone on the hypophysogenital system in the rat].
C R Hebd Seances Acad Sci. 1960 Mar 14;250:2070-2.

[Clinical tests of Methandrostenolone. Its influence on the menstrual cycle of the normal woman].
Dia Med. 1961 Mar 23;33:318-20.

[Comparative studies of the action of testosterone and Methandrostenolone on the rat ovary].
Arch Ostet Ginecol. 1961 Nov-Dec;66:714-21.

Suppressor effect of the anabolic agent Methandrostenolone (Dianabol) on human pituitary gonadotropin excretion.
Bull Sci Issue. 1963 Jan;9:7-13.

[Effects of metandiennone (Geabol, Dianabol) on pituitary function].
Sparrevohn S, Friis T.
Ugeskr Laeger. 1966 Feb 10;128(6):171-7.

Effects of an anabolic steroid (metandienone) on spermatogenesis.
Holma PK.
Contraception. 1977 Feb;15(2):151-62.

[Treatment of male hypogonadism].
Sil’nitskiĭ PA.
Sov Med. 1985;(6):46-50. Russian.

Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin.
Menon DK.
Fertil Steril. 2003 Jun;79 Suppl 3:1659-61


Ugeskr Laeger. 1963 Aug 23;125:1166-7.

Effect of testosterone and anabolic steroids on the size of sebaceous glands in power athletes.
Király CL, Collan Y, Alén M.
Am J Dermatopathol. 1987 Dec;9(6):515-9.

The dark side of beauty: acne fulminans induced by anabolic steroids in a male bodybuilder.
Kraus SL, Emmert S, Schön MP, Haenssle HA.
Arch Dermatol. 2012 Oct;148(10):1210-2.

Metabolism. 1965 Aug;14:891-8.

Hepatotoxicity (Liver)
Studies of hepatic function during methandienone therapy.
Lancet. 1961 Jan 14;1(7168):69-75.

[The effects of Methandrostenolone on the human liver].
Klin Wochenschr. 1961 Oct 1;39:1006-13.

Death due to liver failure following the use of Methandrostenolone.
Can Med Assoc J. 1962 Oct 6;87:768-9.

Dtsch Med Wochenschr. 1963 Oct 11;88:1979-85.

Stud Cercet Med Interna. 1964;38:389-96.

Cholestatic drugs and bilirubin metabolism.
Hargreaves T.
Nature. 1965 Apr 10;206(980):154-6.

[The effect of Methandrostenolone on the glycogen content of the liver and several pathochemical changes in lipid metabolism in experimental chronic toxic hepatitis].
Abdullaev NKh.
Probl Endokrinol Gormonoter. 1966 Jul-Aug;12(4):106-10.

Liver regeneration in the presence of high levels of steroid hormones.
Gershbein LL.
Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1063-7.

Effect of Methandrostenolone on blood lipids and liver function tests.
Verdy M, Tetreault L, Murphy W, Perron L.
Can Med Assoc J. 1968 Feb 24;98(8):397-401.

[Liver toxicity of anabolic steroids].
Rozman C, Urbano A, Galera H.
Munch Med Wochenschr. 1971 Jun 18;113(25):965-7.

[Hepatotoxicity of anabolic steroids].
Rozman C, Urbano A, Galera H.
Minerva Med. 1971 Jun 27;62(51):2605-11.

[Anabolic steroids in the treatment of liver diseases].
Mossor-Ostrowska J.
Pol Tyg Lek. 1971 Aug 9;26(32):1248-51..

[Anabolic steroids and the functional state of the liver].
Volkov NF, Galkin LP, Petlitskiĭ SI, Stolpinskiĭ AA.
Ter Arkh. 1972 Dec;44(12):71-5.

[Liver lesions due to long-term use of anabolic steroids and oral contraceptives].
Bakker K, Brouwers TM, Houthoff HJ, Postma A.
Ned Tijdschr Geneeskd. 1976 Dec 11;120(50):2214-20.

[Effect of nerobol and its combinations with choline and splenin on liver function].
Shevchenko AV, Doroshenko NM.
Vrach Delo. 1978 Sep;(9):76-9.

[Effect of anabolic steroids on liver function in severe forms of chronic circulatory insufficiency].
Bondarenko IP.
Vrach Delo. 1979 May;(5):20-3.

Hepatic angiosarcoma associated with androgenic-anabolic steroids.
Falk H, Thomas LB, Popper H, Ishak KG.
Lancet. 1979 Nov 24;2(8152):1120-3.

Structural alterations of liver parenchyma induced by anabolic steroids.
Stang-Voss C, Appell HJ.
Int J Sports Med. 1981 May;2(2):101-5.

[Severe cholestasis with kidney failure from anabolic steroids in a body builder].
Habscheid W, Abele U, Dahm HH.
Dtsch Med Wochenschr. 1999 Sep 10;124(36):1029-32.

Cholestatic jaundice, acute kidney injury and acute pancreatitis secondary to the recreational use of Methandrostenolone: a case report.
Rosenfeld GA, Chang A, Poulin M, Kwan P, Yoshida E.
J Med Case Rep. 2011 Apr 6;5:138.

Cholestasis secondary to anabolic steroid use in young men.
Elsharkawy AM, McPherson S, Masson S, Burt AD, Dawson RT, Hudson M.
BMJ. 2012 Feb 2;344:e468.

[Cholestasis in young men after taking anabolic steroids].
Elsharkawy AM, McPherson S, Masson S, Burt A, Dawson RT, Hudson M.
Praxis (Bern 1994). 2012 May 9;101(10):661-4.

Acute hepatitis and fevers in an amateur body-builder: a new complication of synthetic androgen abuse?
Girgis CM, Kuo I, Handelsman DJ.
Endocr Pract. 2014 Aug;20(8):e130-3.

Cardiovascular (Cholesterol / Lipid)
Lancet. 1964 Apr 11;1(7337):828-9.

Effect of a C17-alkylated steroid Methandrostenolone on plasma lipids of normal subjects.
Srikantia SG, Rao KS, Prasad PS.
Am J Med Sci. 1967 Aug;254(2):201-4.

[Contribution to the study of anabolic drugs in hyperlipoproteinemias].
Melo E, Leon N, Genta EN, Coelho Neto A, Wajchenberg B, Timoner J.
Arq Bras Endocrinol Metabol. 1967 Dec;16(3):163-72.

Effect of Methandrostenolone on blood lipids and liver function tests.
Verdy M, Tetreault L, Murphy W, Perron L.
Can Med Assoc J. 1968 Feb 24;98(8):397-401.

[Blood cholesterol changes in the course of prolonged treatments with Methandrostenolone, oxymesterone and nandrolone].
Zeneroli ML.
Endocrinol Sci Cost. 1970 May;31(2):107-14.

Effect of Methandrostenolone on serum triglyceride and cholesterol levels in diabetic patients.
Romics L, Bretán M, Szigeti A, Varsányi-Nagy M.
Acta Med Acad Sci Hung. 1975;32(1):27-34.

Effect of anabolic steroids on rat heart muscle cells. I. Intermediate filaments.
Behrendt H.
Cell Tissue Res. 1977 May 31;180(3):303-15.

Severe depression of high-density lipoprotein cholesterol levels in weight lifters and body builders by self-administered exogenous testosterone and anabolic-androgenic steroids.
Webb OL, Laskarzewski PM, Glueck CJ.
Metabolism. 1984 Nov;33(11):971-5.

Serum lipids in power athletes self-administering testosterone and anabolic steroids.
Alén M, Rahkila P, Marniemi J.
Int J Sports Med. 1985 Jun;6(3):139-44.

[HDL breakdown in an athlete taking anabolic steroids].
Heim J, Polard E.
Presse Med. 1996 Mar 16;25(9):458. French.

Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a)
Hartgens F, Rietjens G, Keizer HA, et al.
British Journal of Sports Medicine 2004;38:253-259.

Kidneys (Renal)
Ter Arkh. 1964 Aug;36:79-85.

[The effect of anabolic steroids on the course of uremia].
Krotov VP.
Biull Eksp Biol Med. 1966 Jul;62(7):34-7.

[Effect of Methandrostenolone in chronic renal insufficiency].
Timoner J, Melo E, Genta E, Goussinsky M, Shnaider J, Wajchenberg BL, Mattar E.
Rev Hosp Clin Fac Med Sao Paulo. 1967 Mar-Apr;22(2):95-9.

[Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term].
Révai T, Sápi Z, Benedek S, Kovács A, Kaszás I, Virányi M, Winkler G.
Orv Hetil. 2003 Dec 7;144(49):2425-7.

Evaluation of anabolic steroid induced renal damage with sonography in bodybuilders.
Kantarci UH, Punduk Z, Senarslan O, Dirik A.
J Sports Med Phys Fitness. 2018 Nov;58(11):1681-1687.

The Potential Effects of Anabolic-Androgenic Steroids and Growth Hormone as Commonly Used Sport Supplements on the Kidney: A Systematic Review
D Davani-Davari et al.
BMC Nephrol. 2019 May 31;20(1):198


Violent crime possibly associated with anabolic steroid use.
Conacher GN, Workman DG.
Am J Psychiatry. 1989 May;146(5):679.

Anabolic-androgenic steroid and adrenal steroid effects on hippocampal plasticity.
Clark AS, Mitre MC, Brinck-Johnsen T.
Brain Res. 1995 May 8;679(1):64-71.

Anabolic-androgenic steroids and brain reward.
Clark AS, Lindenfeld RC, Gibbons CH.
Pharmacol Biochem Behav. 1996 Mar;53(3):741-5.

Comparison of the effects of 17 alpha-methyltestosterone, Methandrostenolone, and nandrolone decanoate on the sexual behavior of castrated male rats.
Clark AS, Fast AS.
Behav Neurosci. 1996 Dec;110(6):1478-86.

Anabolic steroid abuse among teenage girls: an illusory problem?
Kanayama G, Boynes M, Hudson JI, Field AE, Pope HG Jr.
Drug Alcohol Depend. 2007 May 11;88(2-3):156-62.

Steroids, psychosis and poly-substance abuse.
Duffy RM, Kelly BD.
Ir J Psychol Med. 2015 Jun;32(2):227-230.


Clinical Uses
[Oral administration of a new anabolic steroid (Methandrostenolone) in pediatric cases].
Minerva Med. 1960 Mar 21;51:990-6.

[Dianabol, an anabolic substance for the treatment of dystrophy in childhood].
Ther Ggw. 1960 Oct;99:466-73.

[Methandrostenolone in children with subnormal weight and/or height].
Prensa Med Argent. 1960 Nov 18;47:3111-7.

[Observations on anabolic therapy with Methandrostenolone in pediatrics].
Minerva Med. 1961 Feb 3;52:363-6.

Role of anabolic hormones (Dianabol) in prepubertal patients with stunted growth.
Chopra IJ, Ahuja MM.
J Assoc Physicians India. 1966 Nov;14(11):667-73.

The effect of anabolic hormones on the growth of undersized boys.
Greene R, Carstairs LS.
Br J Clin Pract. 1973 Jan;27(1):3-7.

Malnutrition / Body Composition / Wound Healing :
[Action of Methandrostenolone in constitutional thinness].
Dia Med. 1960 May 5;32:796-800.

[Statistical proofs of the action of small doses of an anabolic drug (Methandrostenolone) on body weight].
Presse Med. 1961 Sep 16;69:1638.

Methandrostenolone in the treatment of the chronically ill.
Appl Ther. 1962 Aug;4:720-3.

The effect of Methandrostenolone on nitrogen excretion following open-heart surgery.
Zingg W.
Can Med Assoc J. 1965 Oct 9;93(15):816-7.

[Experience with local anabolic therapy of unfavorably healing wounds].
Suckert R.
Wien Med Wochenschr. 1966 Mar 12;116(11):241-2.
Methandienone–an anabolic agent in underweight healthy subjects.
Doshi JC, Vaidya A, Gudibanda KK, Gupta KC, Karandikar PV, Sheth UK.
Indian J Med Sci. 1966 Oct;20(10):674-6.

The effect of methandienone (an anabolic steroid) on nitrogen metabolism following surgical trauma.
Patnaik DN, Nath R, Pathak IC.
Indian J Med Res. 1969 Sep;57(9):1751-60.

Starvation and anabolic steroids.
Krizek V, Stepanek P, Sadilek L.
Metabolism. 1969 Jul;18(7):585-92.

Arthritis / Bone Metabolism
Inhibition of negative nitrogen balance by an anabolic agent (Methandrostenolone) during corticosteroid therapy (dexamethasone) in rheumatoid arthritis.
Metabolism. 1962 May;11:524-9.

J Exp Med Sci. 1964 Mar;8:116-24.

[Calcium and magnesium metabolism in patients with active rheumatism during treatment with anabolic steroids].
Kuz’min IuP.
Ter Arkh. 1976;48(5):87-90.

Calcium, vitamin D and anabolic steroid in treatment of aged bones: double-blind placebo-controlled long-term clinical trial.
Inkovaara J, Gothoni G, Halttula R, Heikinheimo R, Tokola O.
Age Ageing. 1983 May;12(2):124-30.

Haemoglobin response to anabolic steroid in iron-deficiency anaemia.
Victor G, Shanmugasundaram K, Krishnamurthi CA, Rex PM, Nagarajan D.
J Assoc Physicians India. 1967 Apr;15(4):177-83.

Methandienone (an anabolic steroid) in iron deficiency anaemia.
Elhence GP, Jain SC.
Indian J Med Sci. 1969 Apr;23(4):193-5.

Androgens and erythropoiesis.
Evens RP, Amerson AB.
J Clin Pharmacol. 1974 Feb-Mar;14(2):94-101.

Effect of anabolic steroids on plasma antithrombin III. alpha2 macroglobulin and alpha1 antitrypsin levels.
Walker ID, Davidson JF, Young P, Conkie JA.
Thromb Diath Haemorrh. 1975 Sep 30;34(1):106-14.

Anabolic steroids in aplastic anaemia.
Kochupillai V, Sharma S, Sundaram KR.
Indian J Med Res. 1984 Aug;80:174-9.

Bleeding oesophageal varices associated with anabolic steroid use in an athlete.
Winwood PJ, Robertson DA, Wright R.
Postgrad Med J. 1990 Oct;66(780):864-5.

[The mechanism of the thymolytic action of anabolic steroids].
Semeĭkin AV, Stanevskaia TIu, Chermnykh NS, Sergeev PV.
Farmakol Toksikol. 1991 Jul-Aug;54(4):37-8.

[The effect of anabolic steroids on proliferative activity of thymocytes].
Sergeev PV, Semeĭkin AV, Dukhanin AS, Solov’eva EV.
Biull Eksp Biol Med. 1991 Oct;112(10):393-5.

[Use of Methandrostenolone in the combined treatment of iron-deficiency anemia patients].
Babak GIa.
Vrach Delo. 1983 Nov;(11):34-6.

Arch Argent Tisiol Neumonol. 1963;39:31-5.

Adrenocortical / Cortisol Hormones
Interaction of Methandrostenolone and adrenocortical hormones.
Proc Soc Exp Biol Med. 1962 Jun;110:259-62.

Effect of an anabolic steroid (methandienone) on the metabolism of cortisol in the human.
J Endocrinol. 1962 Oct;25:211-20.

Effect of an anabolic steroid (methandienone) on pituitary-adrenal function in the human.
J Endocrinol. 1962 Oct;25:199-209.

Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol.
Barbosa J, Seal US, Doe RP.
J Clin Endocrinol Metab. 1971 Feb;32(2):232-40.

[Effects of weakly androgenic anabolic steroids on growth in Turner’s syndrome].
Muritano MR, Job JC.
Arch Fr Pediatr. 1985 Apr;42(4):265-71.

Carbohydrate / Insulin Metabolism
Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man.
Metabolism. 1962 May;11:501-12.

Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man. II. Effect of methandienone on response to glucagon, adrenalin, and insulin in the fasted subject.
Metabolism. 1962 May;11:513-23.

Am J Med Sci. 1965 Mar;249:280-90.

[The effect of insulin on the anabolic action of dianabol].
Wiśniewski K, Kiluk S, Danysz A.
Acta Physiol Pol. 1966 Sep-Dec;17(5):841-7.

Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol).
Godsland IF, Shennan NM, Wynn V.
Clin Sci (Lond). 1986 Dec;71(6):665-73.

Athletes and Strength Training
Anabolic steroid: effects on strength development.
Johnson LC, O’Shea JP.
Science. 1969 May 23;164(3882):957-9.

[Anabolic steroids and sports].
Imhof P.
Schweiz Z Sportmed. 1970;18(2):79-85.

Anabolic steroids in athletics.
Freed D, Banks AJ, Longson D.
Br Med J. 1972 Sep 23;3(5829):761.

The effect of an anabolic steroid on strength and lean body mass.
Ward P.
Med Sci Sports. 1973 Winter;5(4):277-82.

Anabolic steroid: effectiveness as an ergogenic aid to experienced weight trainers.
Stamford BA, Moffatt R.
J Sports Med Phys Fitness. 1974 Sep;14(3):191-7.

Anabolic steroids in athelics: crossover double-blind trial on weightlifters.
Freed DL, Banks AJ, Longson D, Burley DM.
Br Med J. 1975 May 31;2(5969):471-3.

Proceedings: Effects of methandrostenolone on body composition in male students undergoing athletic training.
Hervy GR, Hutchinson I, Knibbs AV.
J Endocrinol. 1975 Jun;65(3):49P.

A double-blind crossover trial of methandienone (Dianabol, CIBA) in moderate dosage on highly trained experienced athletes.
Freed DL, Banks AJ.
Br J Sports Med. 1975 Jul;9(2):78-81.

Effects of large doses of anabolic steroids.
Harkness RA, Kilshaw BH, Hobson BM.
Br J Sports Med. 1975 Jul;9(2):70-3.

The effects of large doses of the anabolic steroid, methandrostenolone, on an athlete.
Kilshaw BH, Harkness RA, Hobson BM, Smith AW.
Clin Endocrinol (Oxf). 1975 Sep;4(5):537-41.

“Anabolic” effects of methandienone in men undergoing athletic training.
Hervey GR, Hutchinson I, Knibbs AV, Burkinshaw L, Jones PR, Norgan NG, Levell MJ.
Lancet. 1976 Oct 2;2(7988):699-702.

Effect of an anabolic steroid (metandienone) on central and peripheral blood flow in well-trained male athletes.
Holma P.
Ann Clin Res. 1977 Aug;9(4):215-21.

Human strength and endurance responses to anabolic steroid and training.
Loughton SJ, Ruhling RO.
J Sports Med Phys Fitness. 1977 Sep;17(3):285-96.

Metabolic effects of anabolic steroid on skeletal muscle.
Rogozkin V.
Med Sci Sports. 1979 Summer;11(2):160-3.

Effects of methandienone on the performance and body composition of men undergoing athletic training.
Hervey GR, Knibbs AV, Burkinshaw L, Morgan DB, Jones PR, Chettle DR, Vartsky D.
Clin Sci (Lond). 1981 Apr;60(4):457-61.

[The effect of anabolic androgenic steroids on muscle strength, body weight and lean body mass in body-building men].
Søe M, Jensen KL, Gluud C.
Ugeskr Laeger. 1989 Mar 6;151(10):610-3..

Misuse of anabolic drugs.
Robinson RJ, White S.
BMJ. 1993 Jan 2;306(6869):61.

Medico-legal aspects of doping.
Madea B, Grellner W, Musshoff F, Dettmeyer R.
J Clin Forensic Med. 1998 Mar;5(1):1-7.

Prevalence and awareness of Anabolic Androgenic Steroids (AAS) among gymnasts in the western province of Riyadh, Saudi Arabia.
Al Bishi KA, Afify A.
Electron Physician. 2017 Dec 25;9(12):6050-6057.

Modulation of exercise training related adaptation of body composition and regulatory pathways by anabolic steroids.
Reitzner SM, Hengevoss J, Isenmann E, Diel P.
J Steroid Biochem Mol Biol. 2019 Jun;190:44-53.

Anti – Doping / Fake Supplements
Investigations of anabolic drug abuse in athletics and cattle feed. II. Specific determination of methandienone (Dianabol) in urine in nanogram amounts.
Frischkorn CG, Frischkorn HE.
J Chromatogr. 1978 Apr 21;151(3):331-8.

Research of stimulants and anabolic steroids in dietary supplements.
Baume N, Mahler N, Kamber M, Mangin P, Saugy M.
Scand J Med Sci Sports. 2006 Feb;16(1):41-8.

Doping control for metandienone using hair analyzed by gas chromatography-tandem mass spectrometry.
Bresson M, Cirimele V, Villain M, Kintz P.
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):124-8.

High amounts of 17-methylated anabolic-androgenic steroids in effervescent tablets on the dietary supplement market.
Parr MK, Geyer H, Hoffmann B, Köhler K, Mareck U, Schänzer W.
Biomed Chromatogr. 2007 Feb;21(2):164-8.

Selling androgenic anabolic steroids by the pound: identification and analysis of popular websites on the Internet.
Cordaro FG, Lombardo S, Cosentino M.
Scand J Med Sci Sports. 2011 Dec;21(6):e247-59.

When color fails: illicit blue tablets containing anabolic androgen steroids.
Favretto D, Castagna F, Maietti S, Boscolo-Berto R, Ferrara SD.
J Pharm Biomed Anal. 2013 Sep;83:260-4. doi: 10.1016/j.jpba.2013.05.024.

[Methandienone misuse: interest of medical anti-doping units].
Poussel M, Renaud P, Gambier N, Didelot A, Favre A, Chenuel B.
Therapie. 2014 May-Jun;69(3):249-50. doi: 10.2515/therapie/2014023.

Sensitive enzyme immunoassay for screening methandienone in dietary supplements.
Sýkorová S, Fojtíková L, Kuchař M, Mikšátková P, Karamonová L, Fukal L, Lapčík O, Holubová B.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Sep;35(9):1653-1661.

Drug-drug interaction and doping: Effect of non-prohibited drugs on the urinary excretion profile of methandienone.
Mazzarino M, Khevenhüller-Metsch FL, Fiacco I, Parr MK, de la Torre X, Botrè F.
Drug Test Anal. 2018 Oct;10(10):1554-1565.

Reported Deaths
[Death caused by pulmonary embolism in a body builder taking anabolic steroids (metanabol)].
Siekierzyńska-Czarnecka A, Polowiec Z, Kulawińska M, Rowinska-Zakrzewska E.
Wiad Lek. 1990 Oct 1-15;43(19-20):972-5.

Clenbuterol and anabolic steroids: a previously unreported cause of myocardial infarction with normal coronary arteriograms.
Goldstein DR, Dobbs T, Krull B, Plumb VJ.
South Med J. 1998 Aug;91(8):780-4.

[Acute myocardial infarction in a young man who had been using androgenic anabolic steroids].
Halvorsen S, Thorsby PM, Haug E.
Tidsskr Nor Laegeforen. 2004 Jan 22;124(2):170-2.

Myocardial infarction with intracoronary thrombus induced by anabolic steroids.
Güneş Y, Erbaş C, Okuyan E, Babalik E, Gürmen T.
Anadolu Kardiyol Derg. 2004 Dec;4(4):357-8.

Adolescent ischemic stroke associated with anabolic steroid and cannabis abuse.
El Scheich T, Weber AA, Klee D, Schweiger D, Mayatepek E, Karenfort M.
J Pediatr Endocrinol Metab. 2013;26(1-2):161-5.

Sudden or unnatural deaths involving anabolic-androgenic steroids.
Darke S, Torok M, Duflou J.
J Forensic Sci. 2014 Jul;59(4):1025-8.

Side effects of anabolic steroids used by athletes at Unaizah Gyms, Saudi Arabia: a pilot study.
Almaiman AA, Almaiman SH, Elagamy EI, Al Wutayd O, Almarzuqi M, Alzunaidi R, Alhatlani S, Eid EE.
J Sports Med Phys Fitness. 2019 Mar;59(3):489-495.

Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone).
Lehmann S, Thomas A, Schiwy-Bochat KH, Geyer H, Thevis M, Glenewinkel F, Rothschild MA, Andresen-Streichert H, Juebner M.
Forensic Sci Int. 2019 Oct;303:109925.

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Profile dianabol

In socks and a T-shirt, but without panties, I dug up a phallus with a suction cup in the room, ran into the. Bathtub, where I slapped it against the wall, poured it over with grease and gently planted my ass. Closing my eyes, I began to sit on the rubber dick, trying my best to imagine that in fact this is the guy from the gym gently raping me. From such an explosion of fantasy, I finished in just a couple of minutes, without even touching my penis.

Buff Stars Weigh in on Hollywood's Dirty Secret: Anabolic Steroids

It makes sense to another strange story that happened to me, well, with her participation 4 years ago. We, with my then still passion, decided to introduce my friend Vova and her, maybe both of them were still virgins. Vova got to the point that he really asked me for advice on how and what, but this Olya had never really slept with anyone.

Until she was 20 years old.

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Out of impatience, I wanted to thrust it in, but she managed to whisper. Don't rush my sweet. Tender. Gently, but with pressure.

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